The scientists found in the genome of "vulnerability" contributing to the emergence of schizophrenia

Scientists from mit and Harvard University were able to detect in the human genome, new mutations (there were ten), which dramatically increases the risk of such diseases as schizophrenia, and a number of other disorders. It is likely that the discovery will create the conditions for new pharmacological agents.

Characteristic mutations, scientists have discovered two genes related to the work of glutamate receptors. The latter is able to turn into a drug target. Experts also believe that the genome has other vulnerabilities, which will focus the efforts of researchers in the near future.

The researchers looked at the data Bank containing a vast number of genomes, approximately 100 thousand genomes of healthy people and 25 thousand genomes of people suffering from schizophrenia. After comparing genetic data were able to detect rare mutations, whose presence in 4-50 times increased risk of schizophrenia. The presence of anomalies characterized by SP4 genes, GRIA3 and GRIN2A (they participate in the exchange of signals between nerve cells).

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