Studies of lung cancer based on molecular changes

Smoking may be associated with the development of molecular features of cancer of the respiratory tract. Molecular features associated with the development of chronic obstructive pulmonary disease (according to the latest data of American scientists). "We strive to find the early molecular changes caused by Smoking," says Renat Sokhiev, M.D., associate Professor of genetic medicine at Weill Cornell Medical College, who presented the results of their recent research at the AACR-IASLC (joint conference on molecular medicine). "Our goal is to understand the early pathogenesis of lung cancer, and in developing strategies for preventing lung cancer in most people".

Saklaw and his colleagues in the study, analysed the large and small airway epithelium of healthy nonsmokers, healthy smokers and smokers with chronic obstructive pulmonary disease, which is usually caused by long-term Smoking.

Scientists have come to the following conclusions: Smoking is associated with acquisition of molecular features in great epithelium of the respiratory tract prior to development of the disease. In other words, the human body produces new genes. These results can lead to the development of a diagnostic test, which will be sent to these genetic changes in susceptible people, as suggested by the researchers.

"Ideally, we would like to use these genes in routine analysis, to determine which smokers or even non-smokers at risk of developing lung cancer," said Saklaw.

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