American researchers found that passive Smoking immediately produces a detrimental effect on the established transplant, according to EurekAlert!
Scientists at the University of Texas conducted a series of studies, which have investigated the effects of cigarette smoke in mice, which was recently transplanted tissue particles in the capsule of the kidney. One month prior to transplant one part of the animals were exposed to tobacco smoke.
After the surgery to implant the graft were conducted observations in which were recorded the extent of its survival rate in the group of passive smokers" or in the control group, in the case of the use IMMUNOSUPRESSIVE drugs or cancel them.
According to the results of the experiments it was concluded that passive Smoking has a negative impact on the survival rate of transplant. In the case of passive Smoking, it was noted that the transplanted tissue does not produce those enzymes that are responsible for the immune response. Part of T-lymphocytes stimulated failure in the development of intellidexes, which is responsible for increasing the viability of the tissue.
However, the artificial stimulation of production of intellidexes increased graft survival.
Research conducted under the direction of Dai Zhenhua, first showed the exact process of the negative impact of tobacco smoke on the installed transplant. All statements in this paper in the American Journal of Transplantation.