Obesity impairs responsible for decreased appetite hormone

A long time ago science it is known that the occurrence of obesity due to changes in the organism at the genetic and chemical levels. However, scientists from Baylor College of medicine found that the risk of obesity may extend in other directions. As shown by the results of the study, obesity impedes the hormone that reduces appetite. This study is unique because it was the first to establish the interconnectedness between obesity and disorders of hormonal nature in the brain.

It is known that the hormone leptin, which controls the amount of fat in the body, ceases to be generated in the desired amounts due to obesity.

The same recent study found another hormone that affects similar functions of the body. His name alpha-MSH. It sends signals to the brain that it is time to stop eating, and in addition it stimulates the thyroid gland to burn excess calories. If the synthesis of the mentioned hormone is reduced, it increases the likelihood that people will not be able to lose weight, even in the case that the development of leptin remains normal. During the study, which was conducted on rats, rodents were divided into 2 groups, one of which is for three months, the researchers were given feed with a high content of calories, and the second group of rodents were given traditional food.

After this time, scientists have researched the level of hormones and brain cells of rats, in the result, it was found that included in the first group of animals were worse adapted to a certain type of protein in the brain. Responsible for the production of a protein in the brain is the endoplasmic reticulum. When the stress state of the brain becomes more difficult to process hormones responsible for burning excess calories and reducing appetite. The endoplasmic reticulum in prone obese rats was overloaded, with the result that they had great difficulty processed hormone alpha-MSH compared with rats whose weight was normal.

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