Thiazolidinediones are used as one of the groups of drugs for the treatment of diabetes. They increase the sensitivity of tissues to insulin. However, one side effect of the group of drugs is weight gain. Scientists from the University of Georgia have found some biological mechanism it utilizes. Information about the study published in The Times of India.
In mice, scientists have found cells in the hypothalamus that stimulates hunger. The receptors responsible for the metabolism of glucose, was localized in cells that control feeding behavior of the animal.
Activation of this group of receptors increased the appetite of rodents and a tendency to stock products for the future. In the blockade of receptors appetite animals decreased, with increased hunger.