Considered employees of the University of Cincinnati genetic variant cardiac protein is associated with cardiac arrhythmias. According to experts is the first option cellisvisible protein (cellisvisible protein, rich in histidine), which combined with ventricular arrhythmia and a case of sudden death in patients with dilated cardiomyopathy, the edition of Health News.
Heart in this disease is increasing and is not able to deliver the blood in the proper amount. And a group of scientists, which was led by Vivek Singh, it was found that people with a certain variation of this protein - Ser96Ala is simply unable to produce normal control of calcium in heart cells. Hence, the significant disturbance of cardiac rhythm.
Protein cellisvisible rich in histidine, regulates the uptake and release of calcium in the reticulum sarcoplasmatic network of sacs and tubes located in the cardiac muscle fibers, which are necessary for the storage of calcium ions and normal heartbeat.
To test their findings, scientists have bred mice with protein variants: normal (S96S) and transformed (A96A). It was found that the ability of heart cells to reductions decreased when regulatory violations calcium transformed with protein. And in cases of stress was observed pronounced arrhythmia. In all probability, it was occasioned by the fact that the absorption of calcium were in slow mode and the release mode is most active.