Epilepsy, which is not amenable to conventional treatment methods it is possible to cure. This conclusion came the American scientists from the University of California at San Francisco. They managed to beat the disease after transplantation in adult rodents particular brain cells, according to News-medical.net.
Experts transplanted cells medial ganglion tubercle, the so-called MGE cells. Transplantation allowed to stop the active signals of the excited nervous circuits in the hippocampus. Previous transplantation have not ended successfully, as in previous years, scientists have used other cells.
During an attack of epilepsy neuronal activity increases. Transplantation mentioned cells stopped the process in half of rodents on which the experiments have been conducted. Some of these attacks was lost altogether, and in some rodents, the number of spontaneous seizures was reduced. In addition, scientists were able to find a way to create human MGE-shaped cells in the laboratory.
Many forms of epilepsy appear improper function or loss of inhibitory neurons in the hippocampus. That is improperly functioning of nerve cells, which, if necessary, should inhibit the activity of neurons. MGE cells are primary, which are formed at the stage of the embryo. This type of cells, in turn, can create adult interneurone (inhibitory nerve cells).
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After the rodents were transplanted MGE cells, began the formation of interneurons, already embedded in existing neural network. As a consequence, the attacks stopped, hyperactivity and agitation subsided, and the results of tests performed increased. Mice were observed disorder resembling severe anterior epilepsy, in which seizures arise in the hippocampus.